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Marka dihydrotanshinone I disho Helicobacter pylori, kaliya ma burburin karto biofilm -ka, laakiin sidoo kale waxay dili kartaa bakteeriyada ku dhegan biofilm -ka, kaasoo door ka qaata “rujinta” Helicobacter pylori.

Bi Hongkai, Professor, Dugsiga Daawada Aasaasiga ah, Jaamacadda Caafimaadka ee Nanjing

Xogtii ugu dambeysay ee kansarka adduunka ayaa muujineysa in ka mid ah 4.57 milyan ee kiisaska kansarka cusub ee Shiinaha sannad kasta, 480,000 kiis oo cusub oo kansarka gaaska ah, oo ah 10.8%, ay ka mid yihiin saddexda ugu sarreeya. Dalka Shiinaha oo uu aad ugu badan yahay kansarka caloosha, heerka caabuqa Helicobacter pylori wuxuu gaarayaa 50%, dhibaatada caabbinta antibiyootiguna aad bay u sii xumaanaysaa, taasoo keenta hoos u dhac joogto ah oo ku yimaada heerka dabargoynta.
Dhawaan, kooxda Professor Bi Hongkai, Iskuulka Daawada Aasaasiga ah, Jaamacadda Caafimaadka ee Nanjing, ayaa si guul leh u baartay murashax daroogo cusub oo Helicobacter pylori-Dihydrotanshinone I. - Helicobacter pylori biofilm-ka, badbaadada iyo iska-caabbinta iska-caabbinta, iwm, waxaana la filayaa inay gasho cilmi-baaris horudhac ah oo ah murashaxa daroogada ee Helicobacter pylori. Natiijooyinka waxaa lagu daabacay internetka joornaalka dawooyinka lidka ku ah dawooyinka lidka ku ah dawooyinka lidka ku ah dawaynta iyo dawaynta kimikalka ”.

Heerka fashilka daaweynta ugu horreysa ee daaweynta dhaqameedku waa qiyaastii 10%

Marka la eego mikroskoob, dhererku waa 2.5 micrometer ilaa 4 micrometer, ballacuna waa 0.5 micrometer ilaa 1 micrometer. Helicobacter pylori, oo ah bakteeriya qaloocsan oo “fidisa ilkaha iyo cidiyaha qoob -ka -ciyaarka”, kaliya ma sababi karto gastritis ba'an iyo mid daba -dheer, boogaha caloosha iyo duodenal iyo limfaatikada. Cudurada ay ka midka yihiin lymphoma gastric gastric ayaa sidoo kale la xiriira kansarka caloosha, kansarka beerka, iyo sonkorowga.

Daawaynta saddex -laablaha ah iyo afar -laablaha ah oo ay ku jiraan laba antibiyootiko ayaa caadi ahaan laga adeegsadaa waddankeyga si loo daweeyo Helicobacter pylori, laakiin hababka daaweynta dhaqameed ma baabi'in karaan Helicobacter pylori.

“Heerka fashilka ee daaweynta ugu horreysa ee daaweynta dhaqameedku waa qiyaastii 10%. Bukaan -socodka qaarkood waxay yeelan doonaan shuban ama xanuunnada flora caloosha. Kuwo kale ayaa xasaasiyad ka qaba penicillin, waxaana jira antibiyootiko yar oo la kala dooran karo. Isla mar ahaantaana, isticmaalka antibiyootigyada muddada-dheer waxay sababi doontaa bakteeriyada Horumarinta iska-caabbinta maandooriyaha ayaa ka dhigaysa wax-ku-oolnimada antibiyootigga, saamaynta ciribtirkana lama gaari karo haba yaraatee. ” Bi Hongkai wuxuu yiri: “Bakteeriyadu waxay u adkeysataa antibiyootigyada qaarkood, sidoo kale waxay u adkeysan doonaan antibiyootigyada kale, iska caabintu sidoo kale way u kala duwanaan kartaa siyaabo kala duwan. Bakteeriyadu waxay isku faaftaa hidda-wadayaal u adkaysta maandooriyaha, taas oo adkeyneysa iska caabinta daawada bakteeriyada. ”

Marka Helicobacter pylori uu ka hortago duulaanka cadowga, wuxuu si xeeladaysan ugu samaysan doonaa biofilm “dabool difaac ah” naftiisa, biofilm -ku wuxuu yeelan doonaa iska caabin antibiyootiko ah, taasoo dhalisay iska -caabbinta Helicobacter pylori oo kordhaysa, oo saamaynaysa dawaynta iyo yareynta Heerka dawaynta.

Salvia miltiorrhiza tijaabinta unugga waxay joojin kartaa noocyada dawooyinka badan leh

Sannadkii 1994, Ururka Caafimaadka Adduunka wuxuu Helicobacter pylori ku tilmaamay kansarka Nooca I maxaa yeelay wuxuu kaalin hoggaamineed ka qaataa dhacdada iyo horumarinta kansarka caloosha. Sidee loo dabar goyn karaa gacan ku dhiiglahaan? Sannadkii 2017, kooxda Bi Hongkai waxay horumar ka sameeyeen tijaabooyin horudhac ah-Danshen.

Danshen waa mid ka mid ah dawooyinka dhaqameedyada Shiinaha ee sida weyn loogu isticmaalo kor u qaadista wareegga dhiigga iyo ka saaridda istaagga dhiigga. Soosaarradiisa dufanka leh waa xeryaha tanshinone, oo ay ku jiraan in ka badan 30 monomers sida tanshinone I, dihydrotanshinone, tanshinone IIA, iyo cryptotanshinone. Xeryaha Tanshinone waxay leeyihiin saameyno dawooyin oo kala duwan, sida kansarka ka hortagga, bakteeriyada ka hortagga togan, ka-hortagga bararka, dhaqdhaqaaqa estrogen-sida iyo ilaalinta wadnaha, iwm, laakiin saameynta anti-Helicobacter pylori lama soo sheegin.

“Markii hore, waxaan baarnay in ka badan 1,000 monomers dawooyin Shiine ah oo ku jira heerka unugga, ugu dambayntiina waxaan go’aaminnay in dihydrotanshinone I monomer ee Danshen uu saamaynta ugu fiican ku lahaa dilka Helicobacter pylori. Markaan sameyneyno tijaabooyinka unugyada, waxaan ogaanay in markii diirad-dianshinone I la isticmaalay Markay tahay 0.125 μg/ml-0.5 μg/ml, waxay horjoogsan kartaa koritaanka noocyo badan oo Helicobacter pylori ah, oo ay ku jiraan antibiyootig xasaasi ah iyo noocyo badan oo dawooyin u adkaysta . ” Bi Hongkai wuxuu sheegay in dihydrotanshinone I sidoo kale ay aad waxtar ugu leedahay Helicobacter pylori ee biofilms. Saameyn dil oo wanaagsan, iyo Helicobacter pylori ma yeelan iska caabin dihydrotanshinone I inta lagu guda jiro marinka joogtada ah.

La yaabka ugu weyn ayaa ah “Marka dihydrotanshinone aan dilo Helicobacter pylori, kaliya ma burburin karto noolaha, laakiin sidoo kale waxay dili kartaa bakteeriyada ku lifaaqan biofilm -ka, kaas oo kaalin ka qaata xididka 'Helicobacter pylori'. “Bi Hongkai ayaa soo bandhigay.

Dihydrotanshinone I ma daaweyn karaa Helicobacter pylori?

Si natiijooyinka tijaabada ay u noqdaan kuwo sax ah, kooxda Bi Hongkai waxay kaloo sameeyeen tijaabooyin baaritaan jiir si ay u sii ogaadaan saameynta dihydrotanshinone I ee Helicobacter pylori.

Bi Hongkai wuxuu soo bandhigay in tijaabadan, laba toddobaad kadib markii jiirarkii uu ku dhacay Helicobacter pylori, cilmi -baarayaashu si aan kala sooc lahayn ugu kala qaybiyeen 3 kooxood, kuwaas oo ah kooxda maamulka isku -jirka ah ee omeprazole iyo dihydrotanshinone I, kooxda maamulka saddex -geesoodka caadiga ah, iyo fosfooraska acid In kooxda xakamaynta kaydka, jiirarka ayaa la siiyay daawo hal mar maalintii 3 maalmood oo xiriir ah.

"Natiijooyinka tijaabada ah waxay muujinayaan in kooxda isku -dhafka ah ee omeprazole iyo dihydrotanshinone I ay leeyihiin hufnaan sare oo ay ku dilaan Helicobacter pylori marka loo eego kooxda caadiga ah ee saddexleyda ah." Bi Hongkai ayaa yiri, taas oo macnaheedu yahay in jiirarka, dihydrotanshinone I uu leeyahay waxqabad dil oo ka sarreeya dawooyinka dhaqanka.

Goorma ayaan Dihydrotanshinone I geli doonaa guryaha dadka caadiga ah? Bi Hongkai wuxuu carrabka ku adkeeyay in Danshen aan si toos ah loogu adeegsan karin ka -hortagga iyo daaweynta caabuqa Helicobacter pylori, iyo monomer dihydrotanshinone I weli ay aad uga fog tahay in laga dhigo daawo loo isticmaali karo caafimaad ahaan. Wuxuu sheegay in tallaabada xigta ay sii wadi doonto barashada habka ficilka dihydrotanshinone I, iyo hagaajinta dawooyinka iyo sunta sunta dihydrotanshinone I ee ka dhanka ah Helicobacter pylori. “Waddada hor marta weli way dheer tahay. Waxaan rajaynayaa in shirkaduhu ka qaybqaadan karaan cilmi-baaris caafimaad kahor oo ay sii wadi doonaan cilmi-baaristaan ​​si ay uga faa'iideystaan ​​bukaanno badan oo qaba cudurrada caloosha. ”